JUPITER, FL – The move toward targeted anti-cancer treatments has produced better outcomes with fewer side-effects for many breast cancer patients. But so far, advances in precision medicine haven’t reached people diagnosed with so-called triple-negative breast cancer.
After the Connecticut General Assembly passed a billion-dollar tax hike in 2015, General Electric warned they might move their corporate headquarters out of the state if then-Gov. Dannel Malloy signed the bill. Malloy went ahead, and the following year General Electric announced the elimination of hundreds of jobs as they packed up the headquarters they’d called home for over 40 years.
It was Entrepreneur Day last week in the School District of Palm Beach County, thanks to the Office of Diversity and Business Practices’ efforts to create awareness of entrepreneurship, innovation, and leadership.
Blooms of toxin-producing algae exploded in both fresh and salt water ecosystems in southern Florida during the summer months of 2018, impacting wildlife and humans living in these marine environments. During harmful algal blooms, species of cyanobacteria release toxic peptides, including microcystins and nodularin into waterways. Human exposure comes from ingestion, direct skin contact, or inhalation and can lead to a variety of symptoms ranging from gastroenteritis, nausea, allergic reactions and skin rashes to hepatic injury and hemorrhage in more severe cases. Microcystins also have been linked to tumor progression and are harmful to renal, immune and reproductive systems.
A researcher from Florida Atlantic University’s Harbor Branch Oceanographic Institute collaborated with the United States Centers for Disease Control and Prevention to test a newly developed immunocapture protein phosphatase inhibition assay (IC-PPIA) method for detection of microcystins and nodularin in human urine. This method uses a commercially available antibody to specifically isolate microcystins and nodularine from human urine prior to measurement.
Results of the study, published in the journal Toxins , demonstrate that the IC-PPIA method developed by the CDC was able to detect low-dose human exposures to microcystins by analysis of urine from three of the 86 urine specimens analyzed by this new method, which yielded positive results with concentrations of 0.055, 0.089 and 0.052 ng/mL MC-LR equivalents. These findings are the first to report microcystin concentrations directly from exposed residents impacted by cyanobacteria in Florida.
“This new test can detect even low-dose human exposure to microcystins and nodularin, so this method will be important as we study the long-term health impacts of harmful algal blooms, especially the low-level concentrations from human inhalation exposure,” said Adam Schaefer, MPH, co-author and an epidemiologist at FAU’s Harbor Branch. “This method could complement water monitoring programs by identifying human exposures to these toxins at the time of harmful algal blooms and will assist our ongoing research to elucidating health effects associated with these algal blooms. This research is a critical step in developing and interpreting clinical diagnostic tests for harmful algal bloom exposure around the world.”
To assess human exposure to microcystins during the 2018 algal blooms, Schaefer and faculty and collaborators from FAU’s Christine E. Lynn College of Nursing, collected urine, nasal swabs and blood from residents of St. Lucie, Indian River, Palm Beach and Martin counties as a part of a cross-sectional exposure study. A comprehensive questionnaire that included questions on potential routes of exposure to the blooms, fish consumption, and demographic data was administered at the time of sample collection.
Study co-authors are Rebekah E. Wharton, Ph.D., senior author; Brady R. Cunningham, Ph.D.; Elizabeth I. Hamelin, M.S.; and Rudolph C. Johnson, Ph.D., all with the Division of Laboratory Sciences, National Center for Environmental Health, CDC; and Sophia M. Guldberg, Oak Ridge Institute of Science, CDC.
Funding for direct human sampling was supported by the FAU Foundation SpringBoard program.
Florida Atlantic University’s Charles E. Schmidt College of Science will host its 2020 “Frontiers in Science” series with seven different lectures on Fridays, beginning Jan. 17 through April 3. All lectures are free and open to the public.
U.S. News & World Report today ranked Lynn University among the nation’s 2020 Best Online Programs. The university’s online bachelor’s degree moved up 44 spots over last year, placing 106 of 345.
Florida Atlantic University’s Christine E. Lynn College of Nursing’s online master’s degree in nursing is ranked No. 7 in the nation for “Best Online Graduate Programs” in 2020 by U.S. News & World Report. The college soared to No. 7 from the No. 23 spot in 2019, and is the top-ranked program for private and public institutions in Florida. FAU’s College of Business, College of Education and overall online bachelor’s programs also made the list this year.
JUPITER, FL — Storing and retrieving memories is among the most important tasks our intricate brains must perform, yet how that happens at a molecular level remains incompletely understood. A new study from the lab of Neuroscience Professor Ronald Davis, PhD, at Scripps Research, Florida, sheds light on one element of that memory storage process, namely the storage and retrieval of a type of hardwired long-term memory.
The graduation rate for students in District-operated schools in Palm Beach County remained stable at 91.6% for the Class of 2019. According to data released on January 9 by the Florida Department of Education, the District’s graduation rate is .1% lower than the 91.7% rate in 2018.
Jupiter-based BioCurity Pharmaceuticals, an early-stage biotechnology company backed by the Palm Beach County Business Development Board (BDB), has launched a crowdfunding campaign to advance the development of drugs that would prevent the side effects of radiation therapy for cancer patients.