Month: June 2018

SOME EXISTING ANTI-CANCER DRUGS MAY ACT IN PART BY TARGETING RNA, STUDY SHOWS

JUPITER, FL – June 28, 2018 – Bolstering the notion that RNA should be considered an important drug-discovery target, scientists at Scripps Research have found that several existing, FDA-approved anti-cancer drugs may work, in part, by binding tightly to RNA, the regulators of the basic activities of life within cells. The research offers another approach for tackling diseases that have been considered “undruggable,” including amyotrophic lateral sclerosis (ALS), muscular dystrophy, cystic fibrosis and certain cancers.

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RESEARCHERS PROVIDE INSIGHT INTO HOW THE MEMORY MOLECULE LIMITS BRAIN PLASTICITY

The brain has an incredible capacity to support a lifetime of learning and memory. Each new experience fundamentally alters the connections between cells in the brain called synapses. To accommodate synaptic alterations, certain areas of the brain are highly plastic, meaning that have the ability to adapt to incoming information. Within an important brain structure for memory, the hippocampus, reside some of the most plastic cells in the entire brain, utilizing the process of synaptic plasticity to remain primed and flexible.

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BOCA RATON REGIONAL HOSPITAL ONE OF FOUR SITES NATIONALLY IN “BREAKTHROUGH THERAPY” CLINICAL TRIAL

Researchers at Boca Raton Regional Hospital’s Marcus Neuroscience Institute (MNI) are one of only four sites nationally to be investigating the effectiveness of using engineered polio virus in the treatment of patients with an aggressive brain tumor – glioblastoma (GBM) multiforme – that has been refractory to conventional chemotherapy and/or radiation.

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SOME EXISTING ANTI-CANCER DRUGS MAY ACT IN PART BY TARGETING RNA, STUDY SHOWS

Bolstering the notion that RNA should be considered an important drug-discovery target, scientists at Scripps Research have found that several existing, FDA-approved anti-cancer drugs may work, in part, by binding tightly to RNA, the regulators of the basic activities of life within cells. The research offers another approach for tackling diseases that have been considered “undruggable,” including amyotrophic lateral sclerosis (ALS), muscular dystrophy, cystic fibrosis and certain cancers. MORE “SOME EXISTING ANTI-CANCER DRUGS MAY ACT IN PART BY TARGETING RNA, STUDY SHOWS”

FAU ENROLLING FOR ALZHEIMER’S PREVENTION RESEARCH PROGRAM

Florida Atlantic University in Boca Raton, Florida is now enrolling volunteer participants in a pioneering international Alzheimer’s disease prevention research program. The Alzheimer’s Prevention Initiative (API) Generation Program is made up of two clinical trials—Generation Study 1 and Generation Study 2—and will test investigational study medications which aim to prevent the onset of Alzheimer’s disease in cognitively healthy people whose genetic makeup puts them at particularly high risk for developing the disease at older ages.

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RESEARCH GRANT FUNDED IN THE BIOLOGICAL SCIENCES DEPARTMENT

Dr. Alex Keene, Associate Professor in the Department of Biological Sciences and Jupiter Life Science Initiative faculty member, has received a four-year National Institute of General Medical Sciences (NIGMS) R01 research grant totaling $450,016 for his collaborative project with fellow principal investigator Dr. Suzanne McGaugh from the University of Minnesota.

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